Agarwal states selective serotonin reuptake inhibitors (SSRIs)—such as Prozac, Zoloft, and Paxil are some of the highest weight-gain offenders. SSRIs work by preventing a receptor in the brain that reabsorbs serotonin, which makes more of this “feel-good” chemical possible to send messages to nerve cells. While that has a positive effect on feelings, it also can regulate appetite. They found that these drugs can indeed increase cravings for carbohydrates.
What you need to do is talk to your physician about going on an antidepressant that causing the least amount of weight gain. Agarwal says bupropion (brand name, Wellbutrin) is an excellent choice for many patients and may actually help weight loss which is a nice perk for those patients who are already overweight, says Agarwal.